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8 minutes ago by 1e-9

Perhaps this is why physical exercise appears to reduce the risk of Alzheimerā€™s disease[1]. Our lymphatic system relies on muscle contractions to move lymph. So, increasing exercise results in increased lymph flow, which might then clear more amyloid-beta from our brain.

[1] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7113559/

4 minutes ago by voisin

Fascinating! As someone not familiar with how the lymph system operates, do you care to explain how muscle contractions outside the brain cause the lymph system in the brain to expel waste? I understood the blood-brain barrier sort of insulated the brain from a lot of this kind of thing.

22 minutes ago by Zababa

In mice. Still, it's nice that it's working (in mice).

26 minutes ago by api

This is fascinating... could Alzheimers be a result of a lymphatic analogue of arteriosclerosis or artery blockage?

If so then maybe similar treatments might work.

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